Aberrant expression of laminin-332 promotes cell proliferation and cyst growth in ARPKD
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چکیده
منابع مشابه
Laminin 5 Regulates Polycystic Kidneys Cell Proliferation and Cyst Formation
LAMININ 5 REGULATES POLYCYSTIC KIDNEYS CELL PROLIFERATION AND CYST FORMATION Dominique Joly, Sophie Berissi, Amélie Bertrand, Laetitia Strehl, Natacha Patey and Bertrand Knebelmann. From Université Paris-Descartes, Faculté de Médecine ; Inserm U813; AP-HP Hôpital Necker-Enfants-Malades, Paris, France Address correspondance to : Bertrand KNEBELMANN, Department of Nephrology, Hôpital Necker-Enfan...
متن کاملLaminin 5 regulates polycystic kidney cell proliferation and cyst formation.
Renal cyst formation is the hallmark of autosomal dominant polycystic kidney disease (ADPKD). ADPKD cyst-lining cells have an increased proliferation rate and are surrounded by an abnormal extracellular matrix (ECM). We have previously shown that Laminin 5 (Ln-5, a alpha(3)beta(3)gamma(2) trimer) is aberrantly expressed in the pericystic ECM of ADPKD kidneys. We report that ADPKD cells in prima...
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متن کاملAberrant expression of SPARC and its impact on proliferation and apoptosis in ADPKD cyst-lining epithelia.
BACKGROUND Autosomal dominant polycystic kidney disease (ADPKD) results from a combination of environmental and genetic factors. Secreted protein acidic and rich in cysteine (SPARC) can be expressed by many different cell types and is associated with development, remodelling, cell turnover and tissue repair. The analysis of SPARC would help evaluate the effect of the unique matricellular glycop...
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ژورنال
عنوان ژورنال: American Journal of Physiology-Renal Physiology
سال: 2014
ISSN: 1931-857X,1522-1466
DOI: 10.1152/ajprenal.00104.2013